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Creative Biolabs Releases Innovative Antibody-Drug Conjugate Development Schemes

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Creative Biolabs Releases Innovative Antibody-Drug Conjugate Development Schemes

March 26
19:12 2024
The CRO unveiled the technical mechanisms behind the development of bispecific ADCs and antibody-oligonucleotide conjugates, representatives of novel conjugate drugs with full potential.

New York, USA – March 26, 2024 – Creative Biolabs, firmly driving innovations in antibody-drug conjugate (ADC) development, expands their solutions to support the research initiatives of worldwide customers and recently published the specifications of their work to design and produce bispecific ADCs and antibody-oligonucleotide conjugates.

“Bispecific antibodies and ADCs have demonstrated their capabilities to treat cancer in various clinical trials, which both possess outstanding drug selectivity and efficacy. The selectivity, internalization, payload delivery efficiency, and acquired resistance of ADCs can be greatly enhanced by bispecific approaches. We can customize bispecific ADCs.” According to a scientist at Creative Biolabs.

Several bispecific ADC options are implemented at Creative Biolabs to enhance the internalization and trafficking to the lysosome, thus maximizing the drug amount delivered to tumor cells at a given dose.

* Fast-internalizing receptor-based bispecific ADCs

* Biparatopic receptor-based bispecific ADCs

In the realm of antibody-oligonucleotide conjugates (AOCs), Creative Biolabs determines to design, engineer, and produce innovative conjugates to overcome the limitations facing conventional oligonucleotide-based therapies, access previously undruggable tissues and cell types, and more effectively target the underlying genetic drivers of diseases. The breakthroughs they have achieved so far are the fruit of their mastery of diverse conjugation chemistries and their tremendous access to versatile conjugation media-linkers.

“Antibody and oligonucleotide can be bridged via covalent and noncovalent conjugation strategies,” according to the scientist, “among which amine conjugation, sulfhydryl conjugation, and carbohydrate conjugation are the most known methods.”

Central to ADC design, the linker modules provided by Creative Biolabs play a pivotal role in connecting the antibody and drug and dictate the mechanisms for drug release. Their clevable and non-clevable linker options ensure optimal stability and controlled drug release, enhancing the therapeutic effectiveness of ADCs and paving the way for the development of next-generation targeted therapies.

Through collaboration and a focus on excellence, Creative Biolabs remains dedicated to supporting research projects and facilitating breakthroughs in ADC development. The company’s expertise and commitment to quality ensure that researchers have access to the tools and resources needed to accelerate their research and develop novel therapies for unmet medical needs.

For more information on Creative Biolabs’ ADC development solutions, visit


Creative Biolabs’ comprehensive range of ADC development solutions underscores their commitment to empowering researchers and pharmaceutical professionals to advance the field of targeted therapeutics. By offering tailored services and cutting-edge technologies in bispecific ADCs, AOCs, and linker modules, the company continues to drive innovation and contribute to the progress of precision medicine and targeted drug delivery approaches.

Media Contact
Company Name: Creative Biolabs
Contact Person: Candy Swift
Email: Send Email
Phone: 1-631-830-6441
Country: United States