Dyskinesia Pipeline Analysis Demonstrates Novel 40+ Therapies at the Horizon Expected to Transform the Treatment Paradigm | DelveInsight
DelveInsight’s, “Dyskinesia Pipeline Insight, 2023,” report provides comprehensive insights about 40+ companies and 45+ pipeline drugs in Dyskinesia pipeline landscape. It covers the Dyskinesia pipeline drug profiles, including Dyskinesia clinical trials and nonclinical stage products. It also covers the Dyskinesia pipeline therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
In the Dyskinesia pipeline report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, Dyskinesia approvals (if any), and product development activities comprising the technology, Dyskinesia collaborations, licensing, mergers and acquisition, funding, designations and other product related details.
Key takeaways from the Dyskinesia Pipeline Report
- DelveInsight’s Dyskinesia Pipeline report depicts a robust space with 40+ active players working to develop 45+ pipeline therapies for Dyskinesia treatment.
- The leading Dyskinesia Companies includes Contera Pharma, VistaGen Therapeutics, Neurolixis, Celon Pharma, Addex Therapeutics, IRLAB Therapeutics AB, MAPLIGHT THERAPEUTICS, Melior Pharmaceuticals, Molomics, Teva Pharmaceutical, Luye Pharma Group, IMAC holdings, Neurocrine Biosciences, PolyCore Therapeutics, SOM Biotech, PharmaTher Inc., Appello Pharmaceutical, Sumitomo Pharma, Trevi Therapeutics, Sinopia Bioscience, SAGE Therapeutics, Adhera Therapeutics, and others.
- Promising Dyskinesia Pipeline Therapies includes JM-010, CP-011, CPL 500036,NLX-112, Dipraglurant, IRL-790, ML-007, Mesocarb, Ketamine, Deutetrabenazine, LPM-3770164, PCT-3012, AQW051, DSP-9632P, AV-101,T 111, SB-0107, SOM3366, and many others.
- The Dyskinesia companies and academics are working to assess challenges and seek opportunities that could influence Dyskinesia R&D. The Dyskinesia pipeline therapies under development are focused on novel approaches to treat/improve Dyskinesia.
To explore more information on the latest breakthroughs in the Dyskinesia Pipeline treatment landscape of the report, click here @ Dyskinesia Pipeline Outlook
Dyskinesia Overview
Dyskinesia’s are involuntary, erratic, writhing movements of the face, arms, legs or trunk. They are often fluid and dance-like, but they may also cause rapid jerking or slow and extended muscle spasms. They are not a symptom of Parkinson’s itself. Rather, they are a complication from some Parkinson’s medications. They may be caused by systemic, metabolic, endocrinologic, structural, vascular, infectious or inherited degenerative conditions, or be toxin- or drug-induced. Dyskinesia’s usually begin after a few years of treatment with levodopa and can often be alleviated by adjusting dopaminergic medications. Younger people with PD are thought to develop earlier motor fluctuations and dyskinesia’s in response to levodopa. Dyskinesia’s may be mild and non-bothersome, or they can be severe. Most people with Parkinson’s prefer to be “on” with some dyskinesia’s rather than “off” and unable to move well.
Latest Developmental Activities in the Dyskinesia Treatment Landscape
- In June 2022, Addex Therapeutics Ltd announced that it had terminated the Phase IIb/III study evaluating dipraglurant as a potential treatment for dyskinesia associated with Parkinson’s disease (PD-LID) due to the slow recruitment of patients.
- In March 2022, Neurocrine Biosciences, Inc. announced that its collaboration partner, Mitsubishi Tanabe Pharma Corporation (MTPC), obtained regulatory approval for DYSVAL® capsules 40 mg (valbenazine) for the treatment of tardive dyskinesia from the Japanese Ministry of Health, Labour and Welfare.
- In November 2021, Neurocrine Biosciences, Inc. announced that it presented new data from its movement disorder program for tardive dyskinesia (TD) at the 2021 Psych Congress scientific meeting being held October 29–November 1, 2021.
- In April 2022, PolyCore Therapeutics secured seed financing to address motor symptoms and Dyskinesia associated with Parkinson’s Disease.
For further information, refer to the detailed Dyskinesia Unmet Needs, Dyskinesia Market Drivers, and Dyskinesia Market Barriers, click here for Dyskinesia Ongoing Clinical Trial Analysis
Dyskinesia Emerging Drugs Profile
JM-010: Contera Pharma
JM-010 is developed as an innovative approach to accelerate the development of new treatment options for Parkinson’s disease patients suffering from dyskinesia.JM-010 acts as a dual molecular switch by which the target efficacies of two existing and safe medications are perfectly fine-tuned to effectively treat the disease. Using a proprietary formulation, JM-010 targets central mechanisms underlying the development of dyskinesia in Parkinson’s disease. JM-010 has successfully demonstrated its efficacy and safety in preclinical studies, as well as in Phase I clinical safety and Phase II clinical proof of concept studies. Currently, JM-010 is undergoing Phase II clinical studies in Europe and US.
NLX 112: Neurolixis
NLX-112 (also known as befiradol or F13640) is a novel compound that activates serotonin 5-HT1A receptors. NLX-112 has two main advantages over older compounds: NLX-112 is extremely selective for the 5-HT1A receptor, with over 1000-fold selectivity compared to other types of receptor types, and NLX-112 is a full agonist at 5-HT1A receptors, maximally activating the receptor. Currently, the drug is in Phase II stage of clinical trial evaluation for the treatment of L-DOPA-induced dyskinesia in Parkinson’s disease.
CPL 500036: Celon Pharma
CPL500-036 is a novel PDE10A inhibitor developed in laboratories of Celon Pharma S.A. It is characterized by high in vitro and in vivo potency, it is highly selective and has good oral bioavailability (F > 70%) and BBB penetration (B/P = 0,4) in rats. Several behavioural studies have confirmed its antipsychotic and precognitive action in rats (MED > 0,03 mg/kg). CPL500-036 is currently investigated in clinical trials. In October 2019 CelonPharma S.A. completed a phase I clinical trial for CPL500-036.Currently, the drug is in Phase II stage of clinical trial evaluation for the treatment of Medication-Induced dyskinesia.
Dyskinesia Pipeline Therapeutics Assessment
There are approx. 40+ key companies which are developing the therapies for Dyskinesia. The companies which have their Dyskinesia drug candidates in the most advanced stage, i.e. phase II include, Contera Pharma.
Request a sample and discover the recent advances in Dyskinesia Ongoing Clinical Trial Analysis and Medications, click here @ Dyskinesia Treatment Landscape
Scope of the Dyskinesia Pipeline Report
- Coverage- Global
- Dyskinesia Companies- Contera Pharma, VistaGen Therapeutics, Neurolixis, Celon Pharma, Addex Therapeutics, IRLAB Therapeutics AB, MAPLIGHT THERAPEUTICS, Melior Pharmaceuticals, Molomics, Teva Pharmaceutical, Luye Pharma Group, IMAC holdings, Neurocrine Biosciences, PolyCore Therapeutics, SOM Biotech, PharmaTher Inc., Appello Pharmaceutical, Sumitomo Pharma, Trevi Therapeutics, Sinopia Bioscience, SAGE Therapeutics, Adhera Therapeutics, and others
- Dyskinesia Pipeline Therapies- JM-010, CP-011, CPL 500036,NLX-112, Dipraglurant, IRL-790, ML-007, Mesocarb, Ketamine, Deutetrabenazine, LPM-3770164, PCT-3012, AQW051, DSP-9632P, AV-101,T 111, SB-0107, SOM3366, and many others.
- Dyskinesia Pipeline Segmentation: Product Type, Molecule Type, Mechanism of Action, Route of Administration
Dive deep into rich insights for drugs for Dyskinesia Market Drivers and Dyskinesia Market Barriers, click here @ Dyskinesia Unmet Needs and Analyst Views
Table of Content
- Introduction
- Executive Summary
- Dyskinesia: Overview
- Pipeline Therapeutics
- Therapeutic Assessment
- Dyskinesia– DelveInsight’s Analytical Perspective
- Late Stage Products (Phase III)
- Drug Name : Company Name
- Drug profiles in the detailed report…..
- Mid Stage Products (Phase II)
- JM-010: Contera Pharma
- Drug profiles in the detailed report…..
- Early Stage Products (Phase I)
- Drug Name : Company Name
- Drug profiles in the detailed report…..
- Preclinical and Discovery Stage Products
- Drug Name : Company Name
- Drug profiles in the detailed report…..
- Inactive Products
- Dyskinesia Key Companies
- Dyskinesia Key Products
- Dyskinesia- Unmet Needs
- Dyskinesia- Market Drivers and Barriers
- Dyskinesia- Future Perspectives and Conclusion
- Dyskinesia Analyst Views
- Dyskinesia Key Companies
- Appendix
Got Queries? Find out the related information on Dyskinesia Mergers and acquisitions, Dyskinesia Licensing Activities @ Dyskinesia Emerging Drugs, and Recent Trends
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